[Comment] Redefining consolidation in primary CNS lymphoma: autologous stem-cell transplantation as the standard

Abstract

There are core principles that command broad consensus in the initial treatment of patients with primary CNS lymphoma (PCNSL). First, induction should consist of a high-dose methotrexate-based polychemotherapy regimen to elicit tumour response. Second, post-induction therapy following response is needed to prevent relapse.1 Beyond these principles, key practice differences persist without consensus on which chemotherapy agents to combine with methotrexate and the optimal post-induction consolidation strategy.