[Comment] Low-dose aspirin: effective cancer chemoprevention in Lynch syndrome

Abstract

Lynch syndrome is a common inherited cancer susceptibility syndrome defined by pathogenic variants in the DNA mismatch repair genes MLH1, MSH2, MSH6, and PMS2, and deletions in EPCAM, which might result in altered expression of MSH2. Colorectal cancer is the most commonly occurring cancer in people with Lynch syndrome, but there is an increased risk of a range of cancers including endometrial and upper gastrointestinal cancers, with a lifetime cancer risk of up to 80%.