Unclassified ยท Medical Literature

[Comment] Enduring NMDA receptor encephalitis

Authors
Eunice Phillips, Sophie N M Binks, Adam Al-Diwani
Journal
The Lancet Psychiatry
Publication date
2026-09-01
Source
rss_lancet_psy
Original record ID
270237
Summary status
error
Analysis status
error
Original last updated
2026-08-17T07:49:35.000Z

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Abstract

The groundbreaking discovery of N-methyl-D-aspartate receptor (NMDAR) encephalitis almost 20 years ago linked the binding of autoantibodies to a specific brain receptor with widespread neuropsychiatric symptoms.1 This disease has always raised questions at the heart of traditional distinctions between neurological and psychiatric illness: a psychotic onset but an unusual one, symptomatic treatments that do not behave as expected, severe illness but often unremarkable structural brain MRI, yet with substantial recovery often possible.