Unclassified · Medical Literature

[Articles] Efficacy of chloroquine plus low-dose primaquine and pyronaridine–artesunate plus low-dose primaquine against Plasmodium vivax malaria in adults and transmission to mosquitoes in Ethiopia: a phase 2/3, observer-masked, randomised, parallel-group trial

Authors
Migbaru Keffale Bezabih, Solomon Sisay, Sinknesh Wolde Behaksera, Jordache Ramjith, Hiwot Teka, Samuel Girma, Amanuel Shimelash, Legesse Alamerie Ejigu, Fikregabrail Aberra Kassa, Bereket Hailegiorgis, Mekonnen Tadesse, Tadesse Misganaw, Addisu Gizat, Abrham Gashaw, Getinet Habtamu, Negash Seyoum Legesse, Natnael Lemessa Hundera, Daniel Woldesenbet Milki, Melat Abdo, Wakweya Chali, Jon Eric Tongren, Jimee Hwang, Teun Bousema, Fitsum G Tadesse
Journal
The Lancet Microbe
Publication date
2026-06-08
Source
rss_lancet_mic
Original record ID
270266
Summary status
error
Analysis status
error
Original last updated
2026-08-17T08:00:10.000Z

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Abstract

Both regimens treated P vivax malaria with high efficacy. Pyronaridine–artesunate plus low-dose primaquine rapidly interrupted transmission. The findings support further evaluation of pyronaridine–artesunate plus low-dose primaquine as a unified treatment strategy in co-endemic settings to improve malaria control and support malaria elimination efforts.