Unclassified · Medical Literature

[Articles] Assessment of dried blood spot and umbilical cord blood samples for the quantification of maternally transferred IgG against the group B streptococcal alpha-like surface proteins in neonates at Kolding Hospital, Denmark: a proof-of-concept, cross-sectional study

Authors
May Murra, Tom Hall, Tine Brink Henriksen, Mohammed Rohi Khalil, Jens Kjølseth Møller, Hans Christian Slotved, Kirsty Le Doare, Stine Yde Nielsen
Journal
The Lancet Microbe
Publication date
2026-06-23
Source
rss_lancet_mic
Original record ID
270273
Summary status
error
Analysis status
error
Original last updated
2026-08-17T08:01:46.000Z

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Abstract

DBSS analysis serves as a reliable method for quantifying neonatal AlpN-specific IgG. Our findings support the use of DBSSs to establish an AlpN-specific SToRR that could facilitate licensure of the maternal AlpN-GBS vaccine. AlpN-specific IgG concentrations in cord serum closely reflect those in neonatal serum, supporting the use of the former as a surrogate marker. Both DBSSs and cord serum samples represent practical alternatives to neonatal serum, especially in settings in which sample collection is challenging.