Unclassified ยท Medical Literature

[Review] WHO assessment of the preclinical antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats

Authors
Valeria Gigante, Richard A Alm, Tamarie Rocke, Daniela Melchiorri, Alexandra M Cameron
Journal
The Lancet Microbe
Publication date
2026-03-27
Source
rss_lancet_mic
Original record ID
270277
Summary status
error
Analysis status
error
Original last updated
2026-08-17T08:03:26.000Z

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Abstract

Life-threatening invasive and mucosal fungal infections are a major, increasingly complex global health problem. Among all population groups, individuals who are immunocompromised face the greatest risk of contracting such infections, and the size of these global populations is growing at a swift pace. Climate change also affects the dynamics of fungal infections. Commercially available antifungal drugs often have a narrow-spectrum activity and below-optimal safety profile. Drug resistance to antifungals is also rising, and the use of fungicides in agriculture plays a role in resistance development.