Nephrology
Iptacopan in IgA Nephropathy — Final 24-Month Data | ClinicLens
New England Journal of Medicine, Volume 395, Issue 5, Page 465-477, July 30, 2026.
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Nephrology
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T-Cell Engager–Mediated HLA Antibody Depletion before Kidney Transplantation | ClinicLens
New England Journal of Medicine, Volume 395, Issue 5, Page 511-513, July 30, 2026.
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Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy | ClinicLens
New England Journal of Medicine, Ahead of Print.
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[Correspondence] PUSH trial limits: why fluids still matter | ClinicLens
We read with interest the Article1 by Alana C Desai and colleagues on the results of the well designed, large-scale Prevention of Urinary Stones with Hydration (PUSH) trial, which evaluated a multicomponent intervention to improve fluid intake and idiopathic urinary stone recurre
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[Correspondence] PUSH trial limits: why fluids still matter – Authors' reply | ClinicLens
We read with interest the Correspondence from Alba Martina Renzullo and Simone Benvenuto regarding results of the Prevention of Urinary Stones with Hydration (PUSH) trial,1 and share their goal of avoiding potentially harmful interpretation of the results. Findings from the PUSH
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[Department of Error] Department of Error | ClinicLens
Abulibdeh R, Agyemang GO, Celi LA, et al. Who's really in the loop? Rethinking oversight in AI-assisted health care. Lancet 2026; 407: 2340–44—In this Viewpoint, the definition of the eGRF abbreviation in the legend of the figure should have read “estimated glomerular filtra
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Efficacy and safety of obinutuzumab in refractory membranous nephropathy: a single-arm meta-analysis. | ClinicLens
Membranous nephropathy (MN) constitutes an autoimmune glomerular disorder and represents the most frequent etiology of primary nephrotic syndrome in adults. Although obinutuzumab exhibits favorable efficacy in managing refractory MN, outcomes diverge across individual investigati
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The NLRP3 inflammasome in chronic kidney disease progression: systematic review of preclinical models reveals a critical gap in pyroptosis research and therapeu
Chronic kidney disease (CKD) affects ~ 850 million people globally. The NOD-like receptor protein 3 (NLRP3) inflammasome has emerged as a central regulator of inflammatory, fibrotic, and mitochondrial injury during CKD pathogenesis. Nevertheless, its consistency across disease mo
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Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen. | ClinicLens
The long-term renal implications of conditions leading to male reproductive surgeries remain unclear. This study evaluated the potential causal relationships between genetic liability to undergoing these surgeries and kidney diseases. Genetic variants associated with four surgery
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Comparative efficacy of lipid-lowering therapies on the cardio-renal-metabolic axis in diabetic kidney disease: a Bayesian network meta-analysis addressing resi
In diabetic kidney disease (DKD), dyslipidemia accelerates renal decline and heart failure risk, making Cardio-Renal-Metabolic (CRM) risk reduction critical. The bidirectional relationship between cardiac and renal dysfunction further highlights the necessity of lipid-lowering th
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Renoprotective effects of curcumin in cats with chronic kidney disease. | ClinicLens
Chronic kidney disease (CKD) in cats is characterized by oxidative stress, inflammation, and apoptosis. Curcumin has shown renoprotective effects in experimental models, but clinical evidence in cats with CKD remains limited. Evaluate whether PO curcumin supplementation (80 mg/ca
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Fractional Flow Reserve-Guided Renal Artery Stenting in Renovascular Hypertension: 1-Year Results of the FAIR Study. | ClinicLens
Whether fractional flow reserve (FFR)-guided revascularization improves outcomes in atherosclerotic renal artery stenosis (ARAS) remains uncertain. This study will evaluate whether the benefit of FFR-guided stenting sustained at 1 year including renal outcomes. FAIR pilot is an i
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Lactiplantibacillus plantarum WJL ameliorates chronic kidney disease by inhibiting fibroblast growth factor 21 adaptive stress response via low protein diet. |
Low-protein diets (LPD) are recommended in chronic kidney disease (CKD) to reduce disease progression. However, their clinical efficacy and safety are debated due to the risk of protein-energy wasting. A deeper mechanistic understanding is therefore required. Herein, the metaboli
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Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial. | ClinicLens
To determine whether a structured early nephrology consultation triggered by a machine-learning acute kidney injury (AKI) risk score (electronic signal to prevent AKI [ESTOP-AKI]) in patients at high risk for stage 2 AKI improves patient outcomes. This randomized clinical trial w
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Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial. | ClinicLen
Extracorporeal membrane oxygenation (ECMO) is increasingly used to treat patients with severe cardiac and pulmonary failure but the complications of acute kidney injury and fluid overload are common. We aimed to determine whether the early initiation of continuous renal replaceme
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Impact of Blood Flow Rate and Duration of Dialysis Session on Nutritional Status in Hemodialysis Patients. | ClinicLens
Background. Chronic kidney disease (CKD) was commonly associated with malnutrition, with many patients exhibiting protein-energy deficiency and muscle wasting. Increasing blood flow rate (BFR) and extending dialysis duration had been considered strategies to improve nutritional o
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The Role of Group Supportive Psychotherapy on Quality of Life and Its Relationship with Heart Rate Variability and Blood Serotonin Levels in End-Stage Renal Dis
Patients with end-stage renal disease (ESRD) undergoing chronic hemodialysis often experience reduced quality of life and autonomic dysregulation. Group supportive psychotherapy may improve psychological well-being through biopsychosocial mechanisms. This study evaluated the effe
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Eight weeks of MitoQ supplementation does not alter kidney function or urinary kidney injury biomarkers in middle-aged and older adults. | ClinicLens
Several human trials have used the mitochondrial antioxidant mitoquinol mesylate (MitoQ). There are no apparent negative consequences on the kidneys following an acute high dose of MitoQ in young adults; however, it remains unclear whether chronic MitoQ influences kidney function
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The Effect of Preoperative Hydration on Cardiac Surgery-Associated Acute Kidney Injury. | ClinicLens
The aim of this study was to determine the effect of preoperative intravenous saline hydration on postoperative renal functions and the prevention of acute kidney injury subsequent to open-heart surgery. Our investigation was designed as a prospective, randomized, and controlled
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Randomized Controlled Trial of a Digital Intervention (KidneyTIME) to Promote Live Donor Kidney Transplantation. | ClinicLens
Digital behavioral interventions are promising to support patients' pursuit of live donor kidney transplantation (LDKT). This study examined the effectiveness of a patient-led digital intervention (KidneyTIME) versus active control on facilitating LDKT. An individually rando
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Application of high-flux hemodialysis combined with hypoxia-inducible factor prolyl hydroxylase inhibitor in the treatment of renal anemia in patients with urem
This study aimed to explore the efficacy of combining high‑flux hemodialysis (HFHD) with a hypoxia‑inducible factor prolyl hydroxylase inhibitor (HIF-PHI) for the treatment of renal anemia among patients with end-stage kidney disease. Sixty-four newly treated maintenance hemodial
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Perioperative intravenous fluid and chronic kidney disease: long-term follow-up of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELI
The Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) randomised trial found that a restrictive intravenous fluid regimen increased the risk of acute kidney injury (AKI) after major abdominal surgery. We examined whether AKI after restrictive fluid ther
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Implementation of Personalised Peritoneal Dialysis Strategies and Their Associations With Dialysis Adequacy, Complication Control, and Quality of Life Improveme
Peritoneal dialysis is an established kidney replacement therapy for people with kidney failure, allowing home-based treatment, autonomy and preservation of residual kidney function. However, large differences in solute transport, fluid balance and treatment adherence make long-t
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Effects of Semaglutide on Body Composition and GFR: A Prespecified Analysis of the SMART Trial. | ClinicLens
Treatment with semaglutide compared with placebo for 24 weeks reduced lean body mass and fat mass in adults with CKD and overweight or obesity. Changes in lean body mass or fat mass during semaglutide treatment did not correlate with changes in creatinine or cystatin C‑eGFR or me
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Hydrating with a higher-fructose sport drink does not worsen acute kidney injury risk during simulated work-related heat stress. | ClinicLens
Fructose-containing soft drinks worsen acute kidney injury (AKI) risk during simulated work-related heat stress (WrHS), but the fructose content is comparatively lower in sport drinks. This study tested the hypothesis that consuming a higher-fructose sport drink exacerbates AKI r
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Acute isometric handgrip exercise enhances cardiac baroreflex sensitivity and lowers systolic blood pressure in chronic kidney disease. | ClinicLens
Chronic kidney disease (CKD) impairs cardiac baroreflex sensitivity (cBRS), contributing to poor blood pressure (BP) control and heightened cardiovascular risk. Emerging evidence indicates that isometric handgrip (IHG) exercise may enhance cBRS in healthy individuals; however, it
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Finerenone in Patients With Chronic Kidney Disease Due to Glomerular Diseases: A Randomized Clinical Trial. | ClinicLens
Glomerular diseases are a leading cause of chronic kidney disease (CKD) and kidney failure. Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces the risk of kidney function loss in CKD, but its effects in individuals with CKD due to glomerular diseases are un
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A Mobile-Based Mindfulness Intervention for Reducing Demoralization in Patients on Maintenance Hemodialysis: Randomized Controlled Trial. | ClinicLens
Patients with end-stage renal disease receiving maintenance hemodialysis experience a substantial symptom burden, and demoralization syndrome-characterized by helplessness, hopelessness, and loss of meaning-is highly prevalent and strongly associated with impaired quality of life
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Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy. | ClinicLens
Calcific uremic arteriolopathy (CUA) is a rare, severe condition affecting patients with chronic kidney disease (CKD). The etiology of CUA is unclear. Here, we aimed to identify factors associated with its development. We reviewed the existing evidence on its pathomechanisms and
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FDA Adds Kidney Injury Warning to OTC Weight-Loss Drug Orlistat | ClinicLens
The US Food and Drug Administration (FDA) approved labeling changes for the over-the-counter (OTC) weight-loss drug orlistat to warn of acute kidney injury risks.
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SGLT2 inhibition modulates metabolic, vascular, and inflammatory molecular markers in the kidney in youth with type 1 diabetes. | ClinicLens
Sodium-glucose cotransporter-2 (SGLT2) inhibitors slow diabetic kidney disease progression, but their intrarenal mechanisms remain incompletely understood, particularly in type 1 diabetes (T1D), where kidney protection has not been definitively established. ATTEMPT (NCT04333823)
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Artificial Intelligence in Renal Transplantation: Current Innovations and Future Horizons. | ClinicLens
This study critically examined the evolving role of artificial intelligence (AI ) in kidney transplantation, aiming to bridge the gap between theoretical promise and clinical implementation. The study evaluated AI -driven innovations across the transplant continuum, from pretrans
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Therapeutic potential of amino acid-based peritoneal dialysis solutions: a systematic review. | ClinicLens
Peritoneal dialysis (PD) offers many advantages over hemodialysis but chronic exposure to bio-incompatible glucose-based PD solutions and continuous absorption of glucose from the dialysate may lead to peritoneal membrane (PM) dysfunction and systemic metabolic complications such
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The Effect of Individualized Teach-Back Education Guided by the Roy Adaptation Model on Treatment Adherence and Coping Skills in Patients Receiving Hemodialysis
AThis randomized controlled trial evaluated the efficacy of an individualized, nurse-led, teach-back method of education intervention guided by the Roy Adaptation Model on treatment adherence and coping processes among adult patients on hemodialysis. Utilizing a parallel-group pr
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Nurse-Led Digital Intervention for Sodium Restriction in Chronic Kidney Disease: Mixed Methods Implementation Study. | ClinicLens
Digital interventions can support sodium restriction in chronic kidney disease; yet, implementation and engagement barriers remain poorly understood. This mixed methods study evaluated a nurse-led digital program for sodium restriction, focusing on 3 key aspects: implementation,
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Population Pharmacokinetic Modeling for the Iminosugar Lucerastat Supports Dose Adaptation in Patients With Fabry Disease and Moderate to Severe Renal Function
Lucerastat is an iminosugar with the potential to provide substrate reduction therapy for the treatment of Fabry disease (FD), an inherited X-linked lysosomal storage disorder. The aims of this study were to develop a population pharmacokinetic (PK) model describing lucerastat pl
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