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Shift work is associated with an increased risk of sleep disorders, yet tailored prevention and treatment programs remain rare and understudied. Cognitive behavioral therapy for insomnia is the first-line treatment for insomnia in the general population. We thus developed an anon
Open articlePsychiatry
Post-traumatic sequelae are theorized to contribute to and maintain psychotic symptoms. The relative contribution of core posttraumatic stress disorder (PTSD) symptoms and those of complex PTSD are understudied. Network analysis was used to examine interactions between psychosis,
Open articlePsychiatry
Adherence to treatment guidelines for agitation in dementia is suboptimal and inconsistent. We designed and evaluated an Integrated Care Pathway (ICP) for the management of agitation in dementia. This was a double-blind randomized controlled trial at 12 inpatient units and long-t
Open articlePsychiatry
Acceptance- and mindfulness-based interventions are effective for improving pain-related outcomes, yet their effects on psychological flexibility have not been meta-analyzed. This systematic review and meta-analysis addressed this gap by comparing these interventions with control
Open articlePsychiatry
Domestic violence remains a major public health challenge with profound consequences for women survivors. Arts-based interventions are increasingly incorporated into community services as culturally responsive recovery approaches for marginalized populations; however, it remains
Open articlePsychiatry
Aggressive behavior in childhood and adolescence represents a persistent developmental and public health concern, with important implications for psychosocial adjustment and long-term wellbeing. Martial arts training, which typically integrates structured physical activity with r
Open articlePsychiatry
Horticultural therapy (HT) is a promising non-pharmacological intervention for geriatric depression. However, the optimal "dose" required for maximum clinical efficacy remains poorly defined. To evaluate the efficacy of HT in alleviating geriatric depression and to quan
Open articlePsychiatry
The American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM) is often referred to as the bible of psychiatry. While clinicians do not always follow its guidance with the reverence that this description would suggest, it is a docume
Open articlePsychiatry
Adolescence and young adulthood can be exciting but vulnerable periods in a person's life, especially for their mental health. In addition to dealing with complex biopsychosocial changes, young people are confronted by institutions, in educational, health, and justice system
Open articlePsychiatry
Despite declining popularity because of misperceived complexity regarding its administration and monitoring, lithium is a relatively straightforward medication to prescribe because it does not undergo the interactions and metabolism of almost all other psychotropic agents.1 Never
Open articlePsychiatry
Youth mental health services are under pressure to do more, sooner, and more equitably.1 In response, countries, including Canada, are investing in service transformations that promise faster access, shorter waits, earlier intervention, and smoother transitions from youth care to
Open articlePsychiatry
Deaths by suicide among higher-education students in England and Wales increased between 2017 and 2019 and then declined, but in 2023 the rate stayed higher than in 2017. Male students accounted for 65% of cases.1 Suicide in young people has been associated with male sex, life tr
Open articlePsychiatry
Antipsychotic drugs are often thought to have minimal effects on negative symptoms of schizophrenia spectrum disorders. In 1985, Tim Crow conceptualised one of the first biologically informed symptom dichotomies, characterising negative symptoms as poorly responsive to treatment.
Open articlePsychiatry
Mental health service gaps remain substantial worldwide, driven in part by ongoing workforce shortages.1 In response, psychological interventions are increasingly task-shared with community health workers, who are predominantly, and in some settings exclusively, female.2 Gender n
Open articlePsychiatry
Body-focused repetitive behaviours (BFRBs), such as hair-pulling disorder (ie, trichotillomania) and skin-picking (ie, excoriation) disorder, affect millions of people worldwide and are associated with considerable distress, functional impairment, and reduced quality of life.1,2
Open articlePsychiatry
Adolescents today represent the largest cohort in history, coming of age amid unprecedented and interacting social, technological, and environmental changes that are fundamentally reshaping young people's lives. At the same time, adolescent mental health is worsening across
Open articlePsychiatry
The Review by Matthew J Burke and colleagues1 highlights the growing recognition that placebo and nocebo effects are biologically grounded phenomena capable of meaningfully influencing clinical outcomes. Burke and colleagues’ synthesis reflects an important shift away from viewin
Open articlePsychiatry
Matthew J Burke and colleagues,1 and the accompanying Editorial,2 rightly argue that placebo and nocebo effects should no longer be treated as nuisance factors, but as pervasive mechanisms that psychiatry should understand and harness. Burke and colleagues’ emphasis on expectancy
Open articlePsychiatry
We read with interest the systematic review and meta-analysis by Jack Wilson and colleagues1 on the efficacy and safety of cannabinoids for mental and substance use disorders. The authors identify a “crucial need for improved study design that includes larger and more representat
Open articlePsychiatry
Jack Wilson and colleagues1 provide an important synthesis of randomised evidence on cannabinoids for mental and substance use disorders; their findings also highlight the limits of inferring real-world safety from trial-based adverse event data alone. The apparent absence of inc
Open articlePsychiatry
Daniel L Blumberger and colleagues1 report an important trial comparing magnetic seizure therapy (MST) with right unilateral ultra-brief (RUL-UB) electroconvulsive therapy (ECT) for major depressive disorder. Their results suggest that MST preserved much of the antidepressant eff
Open articlePsychiatry
Apurva Parikh and Carla Sharp1 argue that debates over treatment dose for personality disorder are too narrow, and that care should shift towards earlier clinical support during developmentally sensitive periods.1 We agree with their argument that prevention is better than interv
Open articlePsychiatry
Wilson J, Dobson O, Langcake A, et al. The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic review and meta-analysis. Lancet Psychiatry 2026; 13: 304–15—In this Article the spacing of the x-axis of figure 2 has be
Open articlePsychiatry
Nourredine M, Jurek L, Hamza T, et al. Pharmacological interventions for ADHD: a systematic review and dose–effect network meta-analysis. Lancet Psychiatry 2026; 13: 485–95—In this Article, the modafinil data in figure 5 has been incorrectly presented as data for guanfacine. The
Open articlePsychiatry
Jewellery is often celebrated as a symbol of beauty, identity, and status in societies worldwide. It adorns bodies, marks milestones in lives, and carries cultural significance. But for some people, jewellery evokes something entirely different—disgust, anxiety, even panic. This
Open articlePsychiatry
Brain lithium concentrations followed serum concentrations closely across the day but aligned between regimens at the standard 12-h post-dose sampling timepoint. These findings directly inform ongoing discussions about the applicability of a common reference range across regimens
Open articlePsychiatry
Consistent with principles of early intervention in mental health, ACCESS Open Minds implementation resulted in improved or equivalent outcomes but also shifted care towards community-based settings, with substantial net cost savings. These cost savings can be realised if novel s
Open articlePsychiatry
GLP-1 receptor agonist treatment was associated with lower rates of hospitalisation in individuals with alcohol use disorder and substance use disorder. This association extended into the first 182 days after discontinuation for alcohol use disorder but not for substance use diso
Open articlePsychiatry
A range of actions, including prioritising mental health on campus and offering targeted support to those at risk (eg, neurodivergent or financially insecure students) could contribute to suicide prevention. Universities should ensure the safety of accommodation and routinely inv
Open articlePsychiatry
Clinicians should be aware of earlier attainment of substantial response of hostility and excitement, then positive symptoms, before substantial reductions in other domains. Treatment changes should not be made prematurely when negative and cognitive and disorganisation symptoms
Open articlePsychiatry
Coercive measures (eg, restraint and seclusion) remain common in child and adolescent psychiatric and residential care despite efforts to reduce their use. We conducted a mixed-methods systematic review of interventions to reduce coercive measure use. Eligible studies were publis
Open articlePsychiatry
Prevalences of anxiety, depression, and related mental health difficulties continue to rise across many high-income countries, while existing treatment services face growing pressures and limited capacity. Alongside formal psychological and pharmacological interventions, everyday
Open articlePsychiatry
Given rising physical inactivity and mental health challenges, time-efficient interventions like High- Intensity Interval Training (HIIT) require rigorous evaluation. This systematic review and meta-analysis synthesized the evidence for HIIT's effects on mental health in ado
Open articlePsychiatry
This study examines for whom and how Organizational Skills Training-Tier 2 (OST-T2, Nissley-Tsiopinis et al., 2024) works for students in grades 3 to 5 with organization, time management, and planning (OTMP) difficulties. The study: (1) investigates subgroup differences for the e
Open articlePsychiatry
Behavioral problem-solving (BPS) consultation is an effective strategy to help teachers implement Tier 1 classroom management practices with fidelity. However, some teachers continue to experience barriers to implementation even when receiving such consultation, suggesting that a
Open articlePsychiatry
Children with conduct problems are at high risk of persisting mental health problems, making them a priority for early intervention. Group-based parent-training is effective but with a substantial failure rate. Based on evidence on the value of involving children, we developed Re
Open articlePsychiatry
Dysregulation of the microbiota-gut-brain axis has been implicated in attention-deficit/hyperactivity disorder (ADHD), but randomized controlled trial evidence for probiotic supplementation remains inconsistent. This systematic review and meta-analysis evaluated the effects of pr
Open articlePsychiatry
Current transcranial magnetic stimulation (TMS) practice uses fixed-percentage motor threshold dosing, conventionally 120% rMT, for depression treatment. Individual anatomical variability may result in substantially different cortical electric-Field (E-Field) strengths across pat
Open articlePsychiatry
Multiple family group therapy (MFGT) using the 4Rs and 2Ss (rules, responsibility, relationships, respectful communication, stress management and social support) framework has demonstrated effectiveness in addressing mental health and behavioural problems in high-income countries
Open articlePsychiatry
The COVID-19 pandemic highlighted a critical need for effective population mental health approaches to target the most prevalent disorders (eg, depression) during periods of elevated community distress. The effectiveness of remotely delivered and web-based interventions should be
Open articlePsychiatry
Continued cannabis use among young people with first-episode psychosis (FEP) has been linked to poorer clinical and functional outcomes (eg, increased symptom severity and higher relapse rates). Digital harm-reduction interventions may represent a promising, person-centered appro
Open articlePsychiatry
This exploratory study examined whether brief high-intensity cycling exercise, performed either before or after a single online Portuguese language lesson, improved language acquisition or retention in older adolescents with ADHD, compared to a resting control condition. Particip
Open articlePsychiatry
Anxiety disorders are associated with a high burden of illness. In patients with treatment-resistant anxiety disorder, management options can be limited. Stellate ganglion block has been reported to reduce anxiety symptoms in Posttraumatic Stress Disorder. We aimed to determine d
Open articlePsychiatry
Background Negative symptoms (NS) of schizophrenia, including avolition, anergia, and social withdrawal cause major functional impairment and have limited treatment options. Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (LDL
Open articlePsychiatry
Mental health conditions are among the fastest growing and most inequitably distributed global disease burdens. Structural determinants- poverty, conflict, climate change, and the COVID-19 pandemic compound a persistent mismatch between internationally developed policy frameworks
Open articlePsychiatry
An increasing age of the workforce necessitates a better understanding of age-related differences in emotions at work to inform age-inclusive workplace policies and practices. This review critically evaluates how age relates to emotion-regulatory strategies at work (emotional lab
Open articlePsychiatry
Borderline personality disorder (BPD) and eating disorders (EDs) frequently co-occur and are associated with heightened clinical severity and emotion dysregulation. This systematic review aimed to synthesize empirical evidence on the effectiveness of dialectical behaviour therapy
Open articlePsychiatry
A systematic review and meta-analysis were conducted to investigate the association between loneliness and hikikomori symptoms. We searched three electronic databases (plus hand search). Our review followed the PRISMA guidelines, and a PROSPERO registration was made. We included
Open articlePsychiatry
To evaluate the effects of acceptance and commitment therapy (ACT) for insomnia compared with waitlist/standard control conditions and cognitive behavioral therapy for insomnia (CBT-I). A systematic review and meta-analysis of randomized controlled trials was conducted. We search
Open articlePsychiatry
During the COVID-19 pandemic, vaccine hesitancy and low risk awareness were also observed in high-risk groups, such as individuals with mental disorders. This study evaluated an educational video aimed at increasing COVID-19 vaccine acceptance in this population. A randomized onl
Open articlePsychiatry
Despite strong links between emotion regulation (ER) difficulties and problem drinking, few studies have directly addressed whether interventions that target ER positively impact drinking outcomes. In a prior Stage 1a/1b behavioral therapies development study, we developed an Emo
Open articlePsychiatry
Ketamine and its enantiomer esketamine are efficacious in 30-35% of the patients with treatment-resistant depression (TRD). Increased serum brain-derived neurotrophic factor (BDNF) following treatment has been proposed as a potential biomarker of antidepressant response. This is
Open articlePsychiatry
Ketamine is a fast-acting intervention for treatment-resistant depression (TRD), yet only a subset of patients show robust clinical response, and the underlying neural mechanisms remain unclear. High-order interactions (HOI) derived from multivariate information theory provide a
Open articlePsychiatry
To evaluate the effects of magnesium supplementation as an adjunct to fluoxetine on serum brain-derived neurotrophic factor (BDNF) levels and cognitive function in patients with depression. Outpatients aged 18 to 50 years diagnosed with depression who were receiving fluoxetine tr
Open articlePsychiatry
Ketamine exerts rapid antidepressant effects. However, currently available ketamine-based treatments are associated with dissociative and cardiovascular adverse effects. To evaluate the antidepressant efficacy and tolerability of KET01, a novel, oral, prolonged-release racemic ke
Open articlePsychiatry
Gut microbiota may influence antidepressant treatment outcomes, yet whether targeted modulation can enhance efficacy remains unclear. We conducted a randomized, double-blind, placebo-controlled trial in patients with major depressive disorder, administering a 2-week course of fec
Open articlePsychiatry
To evaluate the efficacy of adjunct probiotic supplementation ( Lactobacillus helveticus and Bifidobacterium longum ) alongside standard care compared to placebo in older adults with moderate unipolar depression. A randomized, double-blind, placebo-controlled pilot trial was cond
Open articlePsychiatry
Previous research has demonstrated the positive impact of early remission on disease trajectory for patients with major depressive disorder. However, there is a paucity of literature assessing the response trajectory for patients with treatment resistant depression (TRD). These a
Open articlePsychiatry
Approximately 30% of patients treated for major depressive disorder develop treatment-resistant depression (TRD). The STAR*D study demonstrated remission rates decline progressively with each antidepressant failure (37%, 31%, 14%, and 13%, respectively). A single-day individualiz
Open articlePsychiatry
Objective: Postpartum depression (PPD) is a debilitating mood disorder with peripartum onset. Current treatment options are limited in PPD. GH001 is a synthetic inhalation formulation of the psychoactive molecule mebufotenin (5-MeO-DMT). This trial investigated the preliminary ef
Open articlePsychiatry
Prior studies have reported abnormalities in brain volumes and white matter microarchitecture in persistent depressive disorder(PDD). Randomized controlled trials(RCTs) yoked with brain MRIs are needed to discern whether medications change tissue microstructure in patients with p
Open articlePsychiatry
Continuation treatment with sertraline plus olanzapine is associated with lower risk of relapse of remitted psychotic depression than sertraline plus placebo. We examined the effect of continuation pharmacotherapy on health-related quality of life (HRQOL) in remitted psychotic de
Open articlePsychiatry
The purpose of this study was to examine the effects of two patient-level factors, episode duration and severity, on placebo response in antidepressant clinical trials. To do this we conducted a secondary analysis of seven 8-week, randomized, double-blind, placebo-controlled tria
Open articlePsychiatry
HS-10353 is a novel positive allosteric modulator of γ-aminobutyric acid A receptors that is under development for the treatment of major depressive disorder (MDD). This is a double-blind, randomized, placebo-controlled, phase 1 trial comprising single ascending dose (SAD) and mu
Open articlePsychiatry
To explore patient experiences with the RELEASE (Redressing long-term antidepressant use) toolkit resources, including antidepressant hyperbolic tapering plans designed to minimise withdrawal symptoms as part of the RELEASE trial's implementation evaluation to understand wha
Open articlePsychiatry
Ketamine rapidly reduces suicidal ideation in major depressive disorder (MDD), but its effects are transient. Preclinical and clinical studies suggest that ketamine's antidepressant and antisuicidal effects may be partly mediated by mu-opioid receptor (MOR) modulation. The a
Open articlePsychiatry
Psilocybin has been proposed as a rapid-acting antidepressant (onset 6 weeks), but evidence from randomized clinical trials remains limited, particularly in the broader major depressive disorder (MDD) population. To assess short-term and long-term antidepressant effects of psiloc
Open articlePsychiatry
Positive treatment expectations are known to enhance antidepressant efficacy. Experimental placebo studies aim to provide mechanistic insights into this association, yet their findings have not been clearly linked to clinical expectation effects within individual patients. In a r
Open articlePsychiatry
Anxious depression is a negative prognostic factor linked to worse outcomes in major depressive disorder (MDD). However, its role in treatment-resistant depression (TRD) remains unclear. This secondary analysis of the ASCERTAIN-TRD trial investigates the role of anxious depressio
Open articlePsychiatry
Perioperative depressive symptoms (PDSs) are common among patients who undergo major surgery and can lead to worse clinical outcomes. Esketamine has been reported to alleviate PDSs in patients undergoing certain types of surgery. However, there is a lack of evidence from large-sc
Open articlePsychiatry
The clinical trial NCT03866252 investigates the antidepressant effects of lysergic acid diethylamide (LSD) in 61 patients with major depressive disorder (MDD) randomized to low-dose LSD (LD-LSD; 2 × 25 μg) or moderate-to-high-dose LSD (HD-LSD; 100 μg followed by 200 μg) 4 weeks a
Open articlePsychiatry
Background: Suicide is a public health crisis in the US, with limited evidence demonstrating efficacy of treatments for high-risk patients due in part to their exclusion from most clinical trials. This clinical trial evaluates the feasibility and efficacy of adjunctive cognitive
Open articlePsychiatry
The effectiveness of pharmacogenetics to guide prescribing of selective serotonin reuptake inhibitors (SSRIs) for depression remains unclear, despite the well-established association between SSRI pharmacokinetics and genetic variation. To determine whether pharmacogenetic-guided
Open articlePsychiatry
Cognitive neuropsychological models propose that antidepressants exert their therapeutic effects by modifying negative emotional processing biases early in treatment. However, evidence from large, long-term clinical samples is limited. We conducted a mechanistic analysis within t
Open articlePsychiatry
Ketamine may alleviate treatment-resistant depression (TRD) primarily through glutamatergic modulation, with downstream dopaminergic activation. Iron plays an important role in monoaminergic metabolism, that is also implicated in the pathophysiology of TRD. Both Quantitative Susc
Open articlePsychiatry
Depression and existential distress are highly prevalent among patients with advanced cancer, and there is growing evidence for ketamine as a rapidly acting antidepressant in the population, but few studies have examined existential distress outcomes with ketamine treatment. The
Open articlePsychiatry
Interleukin-6 (IL-6) has been implicated as a potential predictor of ketamine response in treatment-resistant depression (TRD). Esketamine, the S-enantiomer of ketamine, produces rapid antidepressant effects and offers improved safety and intranasal administration. To examine whe
Open articlePsychiatry
The relationship between baseline cognitive performance and tardive dyskinesia (TD) is poorly understood. The aim of the study was to evaluate the role of cognitive performance in the development of TD with a specific focus on sex differences. We included 255 participants from th
Open articlePsychiatry
Modest outcomes from pharmacogenomic (PGx) testing in depression may be influenced by low rates of actionable gene-drug interactions. This 12-week pilot pragmatic randomized clinical trial evaluated the effectiveness of selectively targeting PGx testing to depressed Veterans rece
Open articlePsychiatry
The Patient Health Questionnaire-9 (PHQ-9) is widely used to assess depression, and the General Anxiety Disorder-7 (GAD-7) is widely used to assess anxiety, yet the extent to which subtle differences in instruction delivery influence symptom scores is poorly understood. To determ
Open articlePsychiatry
We conducted a health economic evaluation alongside the PROVIDE-C randomised controlled trial which analysed the effectiveness of a model of integrated mental health video consultations for people with depression and anxiety in primary care in Germany in comparison to treatment a
Open articlePsychiatry
This randomized controlled trial (RCT) quantified the effects of resistance exercise training (RET) compared to low-intensity sham RET attention-control (SHAM) on depressive symptoms among young women (18-40y) with analogue Generalized Anxiety Disorder (AGAD). Fifty-five particip
Open articlePsychiatry
Offering behavioral treatment for anxiety in primary care will help to address the anxiety treatment gap. Modular Anxiety Skills Training (MAST) is a transdiagnostic cognitive-behavioral therapy (CBT) intervention for Primary Care Behavioral Health (PCBH) settings. This multi-sit
Open articlePsychiatry
The Unified Protocol (UP) has proven effective for treating emotional disorders; however, its standard format primarily focuses on regulating negative emotions. While difficulties with negative emotion regulation are common across these disorders, difficulties with positive emoti
Open articlePsychiatry
Specific phobia (SPH) is a prevalent anxiety disorder and may involve advanced biological aging. However, limited brain age research has been conducted in anxiety disorders. This mega-analysis investigated brain aging in SPH participants within the ENIGMA-Anxiety Working Group. 3
Open articlePsychiatry
To identify early markers of acute treatment response among youth with anxiety disorders receiving cognitive behavioral therapy (CBT), selective serotonin reuptake inhibitor (SSRI) monotherapy, or their combination. Although many youth with anxiety disorders benefit from CBT or S
Open articlePsychiatry
American Indian and Alaska Native (AI/AN) adolescents experience considerable mental health disparities, yet research on the prevalence of anxiety and depression remains limited. The objectives of this study were to assess available depression and anxiety data among AI/AN adolesc
Open articlePsychiatry
Many children experience significant, impairing anxiety, yet most never access evidence-based support; among those who do, most face long wait-times to be seen. This disconnect reflects a need for intervention approaches that provide rapid access to interim care. Single-session i
Open articlePsychiatry
Cognitive Disengagement Syndrome (CDS), previously known as Sluggish Cognitive Tempo, has increasingly been recognized as a construct distinct from ADHD inattention yet strongly associated with internalizing disorders. This scoping review synthesized evidence from 82 studies publ
Open articlePsychiatry
Rising cases of cognitive disorders, depression, and anxiety underscore the need for new treatments, given the limited effectiveness and side effects of current options. AdipoRon targets adiponectin receptors and shows promise for protecting the brain, reducing inflammation, and
Open articlePsychiatry
The effectiveness of non-specialist provider-delivered care for mood and anxiety disorders has been established, but effects in violence-exposed populations remain unclear. We examine the net effectiveness of psychosocial treatments delivered by non-specialists to adults experien
Open articlePsychiatry
Virtual reality (VR) has the potential to enhance telemental health care (TMH) by enabling accessible, engaging, and personalized treatment from home. Although VR is well-supported for in-person treatment, evidence for telehealth-based VR is limited. Moreover, no prior research h
Open articlePsychiatry
The error-related negativity (ERN) is a measurable brain response to mistakes that is thought to reflect a modifiable cognitive/emotional bias contributing to the development of anxiety disorders. We previously demonstrated that a psychosocial intervention to reduce error sensiti
Open articlePsychiatry
Exposure and behavioral activation have been identified as key therapeutic components in evidence-based treatment for youths with anxiety and depression, respectively. The current study expanded this work to transdiagnostic treatment for youths with anxiety and depression and exa
Open articlePsychiatry
Anxiety disorders show striking sex differences in prevalence, symptoms, and clinical characteristics, shaping how they manifest and are experienced. Here, we report the first sex-specific meta-analysis of genome-wide association studies (GWAS) of anxiety, leveraging two of the l
Open articlePsychiatry
Altered interoceptive processing and reduced tolerance to aversive bodily sensations are core features of anxiety disorders. Maximal voluntary breath-holding time (mvBHT) has been proposed as a simple, objective behavioral index of interoceptive tolerance. This PRISMA-guided syst
Open articlePsychiatry
Generalized anxiety disorder (GAD) is characterized by stress-anxiety reinforcement cycles. Evidence for brief, self-guided, internet-based stress management as an adjunct to pharmacotherapy remains limited. This study aimed to evaluate the efficacy of an 8-week self-guided, inte
Open articlePsychiatry
Observational epidemiological analysis and a meta-analysis of Mendelian randomization (MR) were used to investigate the association between attention-deficit/hyperactivity disorder (ADHD) and asthma in children and adolescents. Based on data from the 1999 to 2004 National Health
Open articlePsychiatry
Nonsuicidal self-injury (NSSI) in adolescents with depressive disorder is characterized by recurrent impulsivity and is a predictor of future suicidal behavior, necessitating effective and feasible interventions. Mindfulness-based cognitive therapy for adolescents (MBCT-A), a fir
Open articlePsychiatry
Positive psychotherapy (PPT) targets the enhancement of well‑being in individuals with major depressive disorder (MDD), and virtual reality (VR) offers an immersive medium for delivering such experiential interventions. However, most VR-based approaches for depression are grounde
Open articlePsychiatry
Research on gender differences in self-stigma among individuals with psychosis is limited. Gender differences have been found in factors associated with self-stigma, such as self-esteem, quality of life, and cognitive insight. This study aimed to determine predictors of self-stig
Open articlePsychiatry
Anxiety disorders are highly prevalent mental health conditions characterized by physiological dysregulation that includes heightened stress responses, low-grade systemic inflammation, and metabolic imbalance, which together contribute to impaired quality of life. Although yoga-b
Open articlePsychiatry
Background: Research has demonstrated the effectiveness of a mobile app-delivered Acceptance and Commitment Therapy (IACT) programme for individuals with posttraumatic stress disorder (PTSD) in their PTSD symptoms. However, there are still few studies on its mediating mechanism.O
Open articlePsychiatry
Background: The Processing of Positive Memories Technique (PPMT) is a brief, memory-based intervention designed to enhance access to detailed positive autobiographical memories (AMs) in individuals with posttraumatic stress disorder (PTSD). Although research suggests that PPMT is
Open articlePsychiatry
Positive Psychotherapy (PPT) is increasingly being studied as a potential treatment option for psychological diseases. In recent years the internet has been incorporated into traditional face-to-face therapy which, if successful in its treatment outcome, could lead to a more econ
Open articlePsychiatry
Antipsychotic medications stimulate appetite and weight gain, contributing to high obesity rates in people with psychotic disorders. It is unknown if these dietary effects habituate over time. This study aimed to determine the dietary intake of young people with a first-episode p
Open articlePsychiatry
This randomized controlled trial (RCT) was conducted in 10 Italian health and maternal-child Centres to evaluate the effects of a Dialogic Book-Sharing (DBS) intervention on parental symptoms of anxiety and depression. Sixty-eight parents of 14-20-month-old infants were recruited
Open articlePsychiatry
Attention-deficit hyperactivity disorder (ADHD) is associated with impairments in real-life decisions, many involving balancing costs and benefits. Increasing dopamine and norepinephrine with stimulant medication improves decision-making in ADHD. However, it is unclear whether st
Open articlePsychiatry
Exercise is suggested to help regulate emotions; however, its role in the underlying cognitive emotion regulation process-starting with a cue, cognitive actions to modify emotions, and desirable emotional changes-has not yet been demonstrated. This study therefore investigates wh
Open articlePsychiatry
Several lines of evidence suggest that vitamin B6 has potential as an antidepressant. It plays a crucial coenzyme role in the synthesis of the neurotransmitters serotonin, gamma-aminobutyric acid (GABA) and dopamine, which are central to mood regulation, and it has been shown tha
Open articlePsychiatry
Breathing exercises are widely used to alleviate anxiety, but most interventions use fixed templates of inhalation, exhalation, and repetition. This study preliminarily explores the feasibility of data-driven personalization of breathing recommendations for general individuals. W
Open articlePsychiatry
Adolescents with depressive symptoms are at increased risk of social functional impairment and are more likely to develop major depressive disorder. Digital interventions offer advantages, such as high accessibility, especially for adolescents. However, evidence on the effectiven
Open articlePsychiatry
Emotional labour (EL) has become a serious concern in the modern workplace due to the rapid development of the service-oriented economy. Existing literature reviews of emotional labour studies leave many questions unexplored. This study addresses these questions by conducting a h
Open articlePsychiatry
Dance-based interventions are increasingly used to support mental health and well-being across clinical, community, and educational contexts. However, the review-level evidence remains conceptually and methodologically fragmented. This quality-sensitive umbrella review synthesize
Open articlePsychiatry
Nightshift nurses commonly suffer from sleep disturbances and occupational stress due to irregular work-sleep rhythms. This Bayesian network meta-analysis (NMA) compared the efficacy of non-pharmacological therapies to identify optimal interventions for improving sleep and reduci
Open articlePsychiatry
The reinforcer pathology model proposed by Warren Bickel and colleagues focuses on within-individual motivational processes involving overvaluation of smaller immediate rewards relative to larger delayed rewards (delay discounting) and high drug reinforcing value (drug demand) as
Open articlePsychiatry
Anxiety disorders are highly prevalent conditions associated with substantial psychosocial burden, and low-level laser therapy auriculotherapy (LLLT-AT) has emerged as a non-invasive intervention with potential neuromodulatory effects for anxiety management. This systematic revie
Open articlePsychiatry
Compared with heterosexual persons, non-heterosexual persons have worse mental health. Sexual Minority Stress Theory (SMST) explains the disparity as resulting from stigma and discrimination. To the extent that heterosexual genetic relatives reared with non-heterosexual persons a
Open articlePsychiatry
Auditory-verbal signal detection tasks (AV-SDTs) are used to study hallucinatory experiences (HEs) in clinical and nonclinical groups, assessing perceptual decision making under ambiguous auditory conditions. Existing findings suggest that HEs are associated with response biases.
Open articlePsychiatry
This Viewpoint discusses developing a taxonomy of AI mental health harm and understanding how to assess and respond to those harms to advance AI safety.
Open articlePsychiatry
This study investigated the effects of ashwagandha root extract (ARE) supplementation on core attention-deficit/hyperactivity disorder (ADHD) symptoms, executive functioning, and patient-reported outcomes in children and adolescents with mild ADHD. Fifty-eight children and adoles
Open articlePsychiatry
Health care professionals are exposed to high levels of occupational stress, emotional exhaustion, and anxiety-depressive symptoms. Digital interventions using mindfulness- and acceptance-based approaches have shown promising results in improving psychological well-being in this
Open articlePsychiatry
Although mobile health (mHealth) interventions serve as potential solutions for addressing mental health problems, evidence on whether mHealth interventions targeting physical activity can reduce psychological distress among generally healthy workers is limited. This study aimed
Open articlePsychiatry
Limited data are available on the long-term effectiveness of internet-based cognitive-behavioral therapy (iCBT) for anxiety among children. To evaluate the association of an iCBT intervention with anxiety in children compared with a psychoeducation control group over 12 and 24 mo
Open articlePsychiatry
Insufficient responses to available treatments for major depressive disorder (MDD) underscores the necessity for innovative therapeutic strategies. This study investigated the efficacy of adjunctive rosiglitazone, an antidiabetic agent with neuroprotective and anti-inflammatory e
Open articlePsychiatry
The gut microbiota is intricately implicated in the pathogenesis of Major Depressive Disorder (MDD), with the vagus nerve serving as a key regulatory bridge. Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) has emerged as a promising non-invasive therapeutic strategy for
Open articlePsychiatry
This study addresses a critical gap in the evidence base for cost-effective psychological interventions for antisocial personality disorder (ASPD) in forensic settings by presenting a full trial-based economic evaluation of mentalisation-based treatment plus probation as usual (M
Open articlePsychiatry
Growing research confirms the efficacy of transdiagnostic cognitive behavioral psychotherapy, that is treatments applicable across multiple diagnoses within a disorder class or spectrum, by examining group-level changes from pre- to posttreatment. However, less is known about int
Open articlePsychiatry
Citicoline and phosphatidylserine (PS) have been proposed as potential neuroprotective and cognitive-enhancing agents; however, evidence of their therapeutic impact across populations with mental disorders remains limited. This systematic review aimed to evaluate the effects of c
Open articlePsychiatry
Persistent physical symptoms such as fatigue following SARS-CoV-2 infection are common and often accompanied by cognitive complaints. Alongside biological mechanisms, psychosocial processes can contribute to symptom persistence. Psychotherapeutic interventions could be beneficial
Open articlePsychiatry
AbstractAlcohol use is a major contributor to morbidity and mortality, but most individuals with problematic alcohol use do not receive evidence-based care or accurate information about drinking. Recommendations on safe levels of alcohol consumption are rapidly evolving, with rec
Open articlePsychiatry
Introduction Afghanistan has experienced decades of war, political instability, displacement, poverty and structural upheaval, all of which are likely to have contributed to the population’s deteriorating mental health. Individual studies and reports describe depression, anxiety,
Open articlePsychiatry
Objectives To explore the cross-sectional and longitudinal associations of poverty, assessed by deprivation index (DI) and income, with anxiety and stress among adults Design Longitudinal cohort observational study Setting A cohort of adults established in 2014–2015 (T1) in Hong
Open articlePsychiatry
Objectives This paper constitutes an intervention development paper, illustrating the application of the person-based approach to planning and developing a digital transdiagnostic intervention to support Portuguese adults in managing their stress and emotions, thereby enhancing t
Open articlePsychiatry
Objective: The rapid expansion of mobile technology has significantly altered children's screen time behaviors, contributing to concerns about excessive usage. These changes are particularly relevant for children with borderline intellectual functioning, in whom unmanaged sc
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